Báo cáo khoa học

Key findings: The SPOT_MAS assay ‘Screening for the Presence Of Tumor by Methylation And Size’ detects the five most common cancers in Vietnam by evaluating circulating tumor DNA in the blood. Here, we validated its performance in a prospective multi-center clinical trial, K-DETEK. Our analysis of 2,795 participants from 14 sites across Vietnam demonstrates its ability to detect cancers in asymptomatic individuals with a positive predictive value of 60%, with 83.3% accuracy in detecting tumor location. We present a case report to support further using SPOT-MAS as a complementary method to achieve early cancer detection and provide the opportunity for early treatment.

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Ngày đăng: 31/01/2023

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Key findings: The article showed that a multimodal liquid biopsy assay based on analysis of cfDNA methylation, CNA and EM could enhance the accuracy for the detection of early- stage breast cancer. By identifying distinct profiles of genome-wide methylation changes (GWM), copy number alterations (CNA), and 4-nucleotide oligomer (4-mer) end motifs (EM) in cfDNA of breast cancer patients, combination model outperformed base models built from individual features, achieving an AUC of 0.91 (95% CI: 0.87-0.95), a sensitivity of 65% at 96% specificity.

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Ngày đăng: 08/05/2023

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Key findings: Our model achieved an area under the curve (AUC) of 0.88, a sensitivity of 89%, and a specificity of 82% in the discovery cohort consisting of 55 PwHCC and 55 healthy participants. In an independent validation cohort of 54 PwHCC and 53 healthy participants, the established model achieved comparable classification performance with an AUC of 0.86 and yielded a sensitivity and specificity of 81%.

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Ngày đăng: 13/03/2023

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Key findings: Somatic mutations were determined in 96 out of 101 CRC patients. Two-thirds of the tumors harbored more than two mutations, and the most prevalent mutated genes were TP53 and APC. Among confirmed germline mutations, 10 pathogenic mutations and 11 variants of unknown significance were identified.

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Ngày đăng: 30/01/2022

Key findings: 41 pathogenic variants in 11 genes were detected in 3.2% individuals. The carrier frequency was 4.2% in people with family or personal history of cancer and 2.6% in those without history. The percentage of mutation carriers for hereditary colorectal cancer syndromes was 1.3% and for hereditary breast and ovarian cancer syndrome was 1.6%. BRCA1 and BRCA2 mutations were the most prevalent with the positive rate of 1.3% in the general cohort and 5.1% in breast or ovarian cancer patients.

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Ngày đăng: 05/01/2022

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Key findings: Somatic mutations were determined in 96 out of 101 CRC patients. Two-thirds of the tumors harbored more than two mutations, and the most prevalent mutated genes were TP53 and APC. Among confirmed germline mutations, 10 pathogenic mutations and 11 variants of unknown significance were identified.

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Ngày đăng: 30/01/2022

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Key findings: Introduce SPOT-MAS based on combining 4 ctDNA signatures for high accuracy in early detection of CRC
AUC: 0.989; SEN 96.8%; SPEC: 97%

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Ngày đăng: 16/12/2022

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Key findings: Detect ctDNA in 90.5% of the pre-operative plasma samples, whereas carcinoembryonic antigen (CEA) was elevated in only 41.3% of them.

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Ngày đăng: 12/12/2022

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Key findings: Asian cohorts show higher TP53 mutation frequency than in Caucasians. Alterations in PIK3CA and PI3K signaling were dominant.

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Ngày đăng: 10/12/2022

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Key findings: Develop a personalized, tumor-informed assay to detect circulating tumor DNA (ctDNA) in liquid biopsy with high sensitivity and specificity using ultra-deep next-generation sequencing (NGS)

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Ngày đăng: 27/04/2022

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Key findings: Evaluate SPOT-MAS performance on detection of 4 common cancer types

AUC 0.93; SEN: 73.9%; SPEC 95.9%

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Ngày đăng: 27/04/2022

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Key finding:

Evaluate plasma mutations as blomarkers for early detection of CRC:
SENS: 56%
SPEC: 98.95%

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Ngày đăng: 22/02/2021

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Key finding:

Explore methylation signatures of 122 NSCLC patients with TKI drug resistance

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Ngày đăng: 12/08/2021

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Key finding:

Identify the mutation profiles of 265 Vietnamese patients with advanced non-small cell lung cancer (NSCLC)

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Ngày đăng: 04/08/2020

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Key finding: Identify cancer actionable mutations of NSCLC using plasma cfDNA

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Ngày đăng: 17/02/2020

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The identification and quantification of actionable mutations are of critical importance for effective genotype-directed therapies, prognosis and drug response monitoring in patients with non-small-cell lung cancer (NSCLC)…

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Ngày đăng: 24/01/2020

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Key finding: Present a novel method to detect cancer-specific mutation in blood samples of NSCLC patients

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Ngày đăng: 16/12/2019

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