ctDNA analysis based on NGS is a global trend
in early cancer detection.
ctDNA can be detected through a blood test and has been shown to be a valuable tool in the cancer early detection, especially for those healthy and asymptomatic.
Cancerous cells are formed in the tumor
Tumor cells, as they are eliminated, release DNA fragments to the bloodstream, called circulating tumor ctDNA
Draw a blood sample (10ml) to extract cell-free DNA from plasma
Apply Next Generation Sequencing to detect 4 different features of ctDNA from tumor cells compared with cfDNA from normal cells . There are 2 possible test results:
Positive test results along with the tumor origin prediction within the screening range of 5 types of cancers based on machine learning algorithms, which supports Doctors to proceed further treatment.
SPOT-MAS test result will be notified to customers after 30 days from the day when Gene Solutions’ lab received the blood sample. Test results will showcase 2 possibilities
How is SPOT-MAS different from hereditary cancer screening tests?
Hereditary cancer screening tests look for genes with mutations linked to cancer risks, and do not tell whether you have cancer at the time of testing.
Clinical validation of SPOT-MAS, Cancer Investigation, 2023
cfDNA enabling large-scale profile of lung cancer patients, Frontiers in Oncology, 2020
Liquid-biopsy and ctDNA methylation, PLOS ONE, 2019
ctDNA technology enables multi-cancer early detection (MCED) through a single blood draw. Non-invasive, convenient, accurate and accessible, the test is very promising in opening a new era in the world’s fight against cancer.
Cancer cells may develop so silently within our body for as long as 12 years without patients being aware of any symptom, until it is too late. Therefore, detecting cancer at early stages determines the efficacy of treatment.
(*) Smoking more than 20 packs/year or passive smokers;
who drink more than 15 cans/week for men and eight cans/week for women;
people who are constantly exposed to toxic substances or a polluted environment.
(**) Family history of having been diagnosed with cancer.
*According to the report of GLOBOCAN 2020, the 5 most common types of cancer in Vietnam include liver cancer (14.5%), lung cancer (14.4%), breast cancer (11.8%), %), stomach cancer (9.8%) and colorectal cancer (9%).
**According to Cancer Investigation (USA) , a research published by Gene Solutions in February 2023 on 2,975 people taking SPOT-MASTM cancer screening test. The test shows its sensitivity of 73.9%, specificity of 95.9%, positive predictive value (PPV) 60%, tumor tissue of origin (TOO) 83.3%
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